One fine way to ensure that nobody will ever publish your book is to become vile. Not criminous, mind you, but vile.
Being, say, convicted scamster Bernard Madoff will not especially deter a major publisher from putting your novel into the stores — although the Son of Sam laws may prevent you from ever seeing a cent of the profits. Possibly you were aware that the late Saddam Hussein took time off from his career as an iron-heeled Iraqi despot to write romance novels. They were of course published, to glowing reviews. Being able to send squads of goons with AKs over to the publisher or reviewer’s house does have an impact; we can amuse ourselves imagining the pull quotes: “Georgette Heyer trembles in her grave at this dawning of a shining new light in the romance universe!”
No, to repel Western publishers you do have to be genuinely and unremittingly repellent. Luckily the Internet allows plenty of scope for this. A sure way to ensure that nobody will publish you (or for that matter hire you, or date you, or run you for political office) is to run a blog full of spleen, raving and bigotry. There are still some things that are beyond the pale. Publishers adore controversy, because controversy draws eyeballs and leads to sales. But they are highly risk-averse. They won’t associate with the truly vile; their lawyers won’t let them. Phillip Garrido‘s chances of publication are zero and falling.
Your novel may be mild as milk, full of bunnies with big eyes and pink clouds and gentle discussions about the Role of Art. But if your blog persona runs to neo-Nazi screeds, child molestation, or the overthrow of the US government by violence, no one will buy it. I promise.