This series of graphic novels is a classic — classic science fiction. 

The basic premise, the death of nearly everything with a Y chromosome, has been handled in one form or another by some of the great SF writers.  The story arcs revolve completely around how society adapts and confronts the new status quo — I particularly admire the way the Washington Monument is repurposed as, of course, a memorial to all the dead men.  Every now and then you can see the authorial thumb on the scales, but it is not too severe.  And Yorick, the appropriately-named hero of the work, is quite a funny guy, so it is not all Grim and Depressing.

I am informed that the work is due to make a leap to the movies sometime — a thrilling possibility!